The lens for my right eye is a high index lens and the left is medium index lens because the power and astigmatism of both eyes are different. But I wonder if this would cause vision problem or affect the way and direction my eye focus?
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Can different index lens in my glasses cause vision problem?
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Yes. Different index lenses will affect the way and direction your eye focus and then cause your discomfort. What's more, different index lenses will make the lenses have different thickness. I think you'd better use high index in both lenses to make them look similar even if you have different power in both eyes.

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